Wnt glycoproteins act as important signaling molecules in a range of processes from development to cancer. Pan et al. (p. 1350) describe a missing link in the mechanism by which … [Read more]

Understanding the nature of host viral resistance factors has provided important insights into antiviral immunity. Certain host genes are known that protect mice against Friend retrovirus infection, but the identity … [Read more]

Many industrial catalysts consist of metal nanoparticles on oxide supports, and in many cases this morphology increases the activity of the metal by increasing its surface area relative to the … [Read more]

Early meteorites show a wide variation in their relative abundances of the three isotopes of oxygen. These variations have generally been explained as a result of self-shielding, in which absorption … [Read more]

Colorectal cancer is one of the leading causes of cancer-related deaths worldwide. Because 20 to 30% of cases occur in individuals with a family history of the disease, genetic factors … [Read more]

The firing patterns of brain neurons recorded from people watching a video episode were the same as those recorded during later recall of the same show.

Authors: Hagar Gelbard-Sagiv, Roy Mukamel, Michal Harel, Itzhak Fried

Comprehensive analysis of mutations in a brain cancer identifies previously unrecognized cancer genes and a frequently mutated protein that may serve as a therapeutic marker.

Authors: D. Williams Parsons, Siân Jones, Xiaosong Zhang, Jimmy Cheng-Ho Lin, Rebecca J. Leary, Philipp Angenendt, Parminder Mankoo, Hannah Carter, I-Mei Siu, Gary L. Gallia, Alessandro Olivi, Roger McLendon, B. Ahmed Rasheed, Stephen Keir, Tatiana Nikolskaya, Yuri Nikolsky, Dana A. Busam, Hanna Tekleab, Luis A. Diaz, Jr. James Hartigan, Doug R. Smith, Robert L. Strausberg, Suely Kazue Nagahashi Marie, Sueli Mieko Oba Shinjo, Hai Yan, Gregory J. Riggins, Darell D. Bigner, Rachel Karchin, Nick Papadopoulos, Giovanni Parmigiani, Bert Vogelstein, Victor E. Velculescu, Kenneth W. Kinzler

Analysis of genome alterations shows that the same 12 signaling pathways are disrupted in most pancreatic tumors, suggesting these as key to tumor development.

Authors: Siân Jones, Xiaosong Zhang, D. Williams Parsons, Jimmy Cheng-Ho Lin, Rebecca J. Leary, Philipp Angenendt, Parminder Mankoo, Hannah Carter, Hirohiko Kamiyama, Antonio Jimeno, Seung-Mo Hong, Baojin Fu, Ming-Tseh Lin, Eric S. Calhoun, Mihoko Kamiyama, Kimberly Walter, Tatiana Nikolskaya, Yuri Nikolsky, James Hartigan, Douglas R. Smith, Manuel Hidalgo, Steven D. Leach, Alison P. Klein, Elizabeth M. Jaffee, Michael Goggins, Anirban Maitra, Christine Iacobuzio-Donahue, James R. Eshleman, Scott E. Kern, Ralph H. Hruban, Rachel Karchin, Nickolas Papadopoulos, Giovanni Parmigiani, Bert Vogelstein, Victor E. Velculescu, Kenneth W. Kinzler

A transmembrane protein induced in cytokine-treated bronchial epithelial cells seems to be a long-sought primary carrier of a voltage- and calcium-dependent chloride current.

Authors: Antonella Caputo, Emanuela Caci, Loretta Ferrera, Nicoletta Pedemonte, Cristina Barsanti, Elvira Sondo, Ulrich Pfeffer, Roberto Ravazzolo, Olga Zegarra-Moran, Luis J.V. Galietta

When irradiated by light, a ruthenium-organic catalyst creates intermediates with unpaired electrons that undergo otherwise intractable asymmetric reactions.

Authors: David A. Nicewicz, David W. C. MacMillan